HOME | CONTACT US

Peer Reviewed Published Studies and Clinical Data

The following research pertains to Umbelliferone derivatives.

The role of umbelliferone derivatives 4MU (4-Methylumbelliferone) as Hyaluronan Syntheses inhibitor , Hyaluronan Syntheses induced Cancer progression, AntiCancer Chemotherapy prophylaxis, sensitizer and enhancer
Cancer Res. 2008 Jan 15;68(2):483-91. Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44.PMID: 18199543 more.......
Cell Biol Int. 2007 Sep;31(9):1022-6. Epub 2007 Mar 20. Suppression of matrix metalloproteinase-9 by 4-methylumbelliferone. PMID: 17470403 more........
Int J Cancer. 2007 Jun 15;120(12):2557-67. Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells. PMID: 17315194 more.......
J Biol Chem. 2006 Aug 25;281(34):24381-9. Epub 2006 Jun 28. Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy.PMID: 16807238 more........
Biochem Biophys Res Commun. 2006 Jul 14;345(4):1454-9. Epub 2006 May 15. Study of hyaluronan synthase inhibitor, 4-methylumbelliferone derivatives on human pancreatic cancer cell (KP1-NL).PMID: 16730656 more.........
Int J Oncol. 2006 Jul;29(1):175-83. HAS3-related hyaluronan enhances biological activities necessary for metastasis of osteosarcoma cells. PMID: 16773198 more.........
Cancer Chemotherapy Pharmacology 2006 Jan;57(2):165-70. Epub 2005 Sep 15. 4-methylumbelliferone, a hyaluronan synthase suppressor, enhances the anticancer activity of gemcitabine in human pancreatic cancer cells. PMID: 16341905 more.........
Exp Cell Res. 2005 Oct 15;310(1):205-17. The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer.PMID: 16125700 more.......
FEBS Lett. 2005 May 9;579(12):2722-6. Epub 2005 Apr 9. A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells. PMID: 15862315 more.........
J Surg Res. 2004 Nov;122(1):70-4. Hyaluronan mediates adhesion of metastatic colon carcinoma cells. PMID: 15522317 more.......
J Biol Chem. 2004 Aug 6;279(32):33281-9. Epub 2004 Jun 9. A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone. PMID: 15190064 more.........
Biochem Biophys Res Commun. 2004 Sep 3;321(4):783-7.

Effect of a hyaluronan synthase suppressor, 4-methylumbelliferone, on B16F-10 melanoma cell adhesion and locomotion. PMID: 15358095 more........

The role of umbelliferone derivatives (4-Meythylumbelliferone) as a anti-diabetic and as a antidiabetic-prophylaxis
Basic lin Pharmacol Toxicol. 2007 Aug;101(2):73-7. Effect of umbelliferone on tail tendon collagen and haemostatic function in streptozotocin-diabetic rats. PMID: 17651305 more.......
Eur J Pharmacol. 2007 Jul 2;566(1-3):231-9. Epub 2007 Apr 10. Protective effect of Umbelliferone on membranous fatty acid composition in streptozotocin-induced diabetic rats. PMID: 17477917 more.......
Pharmacol Rep. 2007 May-Jun;59(3):339-48. Influence of umbelliferone on membrane-bound ATPases in streptozotocin-induced diabetic rats.PMID: 17652835 more.......
J Med Food. 2006 Winter;9(4):562-6. Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats. PMID: 17201745 more.......
Life Sci. 2006 Jun 13;79(3):306-10. Epub 2006 Feb 7. Antioxidant role of Umbelliferone in STZ-diabetic rats. PMID: 16464472 more......
Yale J Biol Med. 2005 May;78(3):133-40. Impact of umbelliferone on erythrocyte redox status in STZ-diabetic rats. PMID: 16464311 more.......
The role of umbelliferone derivatives (4-Meythylumbelliferone) as a choleretic with antispastic
Dtsch Med Wochenschr. 2005 Aug 26;130(34-35):1938-43. Bile acid-independent effect of hymecromone (4-Methylumbelliferone) on bile secretion and common bile duct motility.PMID: 16123896 more......
Drugs Exp Clin Res. 2001;27(5-6):223-31. Hymecromone (4-Methylumbelliferone) in the treatment of motor disorders of the bile ducts: a multicenter, double-blind, placebo-controlled clinical study. PMID: 11951580 more.......
Int J Clin Pharmacol Ther. 1995 Oct;33(10):569-72. Postprandial bile-duct kinetics under the influence of 4-methylumbelliferone (hymecromone). PMID: 8574509 more.......
Vutr Boles. 1982;21(3):17-21. Clinical observations on the therapeutic activity of the preparation mendiaxon (4-Methylumbelliferone) in diseases of the biliary tract. PMID: 7113181 more......
Jpn J Pharmacol. 1977 Feb;27(1):71-8. Studies on increased bile formation produced by polyoxybenzenes in rats.PMID: 864884 more.......
Minerva Med. 1968 Oct 13;59(82):4359-68. Imecromone (4-Methylumbelliferone): a new choleretic with antispastic action on Oddi's sphincter. Clinical pharmacology and clinico-statistical study. PMID: 5683717 more.......
The anti-inflammatory, anti-oxidant, hepatoprotective roles of umbelliferone derivatives (4-Methylumbelliferone)
Free Radic Res. 2007 Oct;41(10):1168-80. Coumarin derivatives protection against ROS production in cellular models of Abeta toxicities.PMID: 17886039 more.......
J Enzyme Inhib Med Chem. 2006 Apr;21(2):157-61. Coumarin Schiff-bases: as antioxidant and possibly anti-inflammatory agents.PMID: 16789429 more.......
J Enzyme Inhib Med Chem. 2006 Feb;21(1):21-9. Antiinflammatory and antioxidant evaluation of novel coumarin derivatives.PMID: 16570501 more.......
J Med Chem. 2005 Oct 6;48(20):6400-8. Synthesis and antiinflammatory activity of coumarin derivatives.PMID: 16190766 more........
Curr Pharm Des. 2004;10(30):3813-33. Natural and synthetic coumarin derivatives with anti-inflammatory/ antioxidant activities.PMID: 15579073 more.......
Medical Opinion Wardle 2003: Compliation of Patient Records - 4-methylumbelliferone (Heparvit) in the treatment of HBV, HCV, Toxic Hepatitis, and Hepatits of Unknown cause. more........
J Enzyme Inhib Med Chem. 2003 Feb;18(1):63-9. Biological evaluation of several coumarin derivatives designed as possible anti-inflammatory/antioxidant agents. PMID: 12751823 more.......
Medical Opinion Invanis 1997 Aug 11. Heparvit (4-Methylumbelliferone) - A treatment for Liver patients with viral and non-viral Hepatitis and elivated Liver enzymes. more.......
University of Zagreb March 1998 Investigation into the Hepatoprotective effect of 4-methylumbelliferone (Heparvit) in mice with Acetaminophen Induced Hepatotoxicity. Dr.mr.sci. Marija Renic, Prof. Dr.sci. Filip Culo, Department of Physiology and Immunology, School of Medicine, Šalata 3, 10 000 Zagreb, Croatia. more.........
Gen Pharmacol. 1996 Jun;27(4):713-22. Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential.PMID: 8853310 more........