CHEMOTHERAPY - ANTICANCER
Prophylaxis + Enhancer + Sensitizer

Chemotherapy is an anticancer drug therapy that can stop cancer cells from multiplying. However, it can also harm healthy cells, and causes adverse side effects.  

BioMonde's response!

The Global

Dependency on Chemotherapy

There are over 200 types of Cancer and over 50 Chemotherapy Drugs available. Cancer chemotherapy is not new, and has been helping people beat cancer since the early 1950s.

    

Problems associated with Chemotherapy treatments 

kills healthy cells;
bone marrow(makes blood cells);
hair follicles;
lining of the mouth;
digestive system.

 

Common

Chemotherapy Drugs

Amsacrine
Bleomycin
Busulfan
Capecitabine
Carboplatin
Carmustine
Chlorambucil
Cisplatin
Cladribine
Clofarabine
Crisantaspase
Cyclophosphamide
Cytarabine
Dacarbazine
Dactinomycin
Daunorubicin
Docetaxel
Doxorubicin
Epirubicin
Etoposide
Fludarabine
Fluorouracil
Gemcitabine
Gliadel implants
Hydroxycarbamide
Idarubicin
Ifosfamide
Irinotecan
Leucovorin
Liposomal doxorubicin
Liposomal daunorubicin
Lomustine
Melphalan
Mercaptopurine
Mesna
Methotrexate
Mitomycin
Mitoxantrone
Oxaliplatin
Paclitaxel
Pemetrexed
Pentostatin
Procarbazine
Raltitrexed
Streptozocin
Tegafur-uracil
Temozolomide
Teniposide
Thiotepa
Tioguanine
Topotecan
Treosulfan
Vinblastine
Vincristine
Vindesine
Vinorelbine

Development of a optimized, safe, effective and affordable class of novel chemo-prophylaxis, chemo-enhancing and chemo-sensitizing umbelliferone derivatives (4-meythylumbellierone).

• a adjunct to Gemcitabine and other anticancer chemotherapy treatments;
• a prophylaxis treatment to maximize the efficacy and minimize the adverse side effects associated with anticancer chemotherapy;
• a therapy to protect healthy cells against chemotherapy damage by targeting and making cancer cells more susceptible to anticancer drugs;
• a therapy to reduce chemotherapy induced inflammation of the Liver;
• a therapy to improve patient recovery during and after chemotherapy treatment; radiation therapy and surgery.

BioMonde is focused on improving the tolerability and effectiveness of chemotherapy drugs by lessening the toxic side effects and improving patient recovery times. Scientific evidence cites the potential of umbelliferone derivatives (4-meythylumbellierone) as a new anticancer strategy, that is able to select cancer cells and mark (sensitize) them as targets for chemotherapy drugs.

Hyaluronan synthases which scientists have identified as a major cause of cancer progression, produces a dense sticky substance that is very problematic to the progression and treatment of cancers. Over expression (over production) of hyaluronan coats the extracellular matrix surface of cancer cells. The hyaluronan coating inadvertently acts as a protective shell, preventing the uptake of anticancer drugs into the cancer cells. Unfortunately, normal cells lack the hyaluronan coating, and are more susceptible to damage from anticancer drugs. The hyaluronan coating also acts as an adhesive for cancer cells that metastases to other parts of the body, causing them to become attached to other tissue types where they propagate.

By suppressing the over expression of hyaluronan synthases, umbelliferone derivatives (4-meythylumbellierone) , prevent and strip the hyaluronan coating on the surface of the cancer cells, exposing the them to the full effects of anticancer chemotherapy drugs, and helps slow the progression of the Cancer. In other words, 4MU actively targets and sensitizes cancer cells for anticancer drugs, making the drugs work better.

Anti-neoplasm derivatives administered in combination with Umbelliferone derivatives (4-meythylumbellierone) exert a potent synergy effect that greatly improves the adjunct effect. Consequently, BioMonde's approach means that more patients will be able to take and complete anticancer chemotherapy treatment, with minimal discomfort and maximum effect.

REFERENCE MATERIAL

Published and  Peer Reviewed Studies click-here

View our product pipeline click-here

Products containing umbelliferone derivatives (4-Methylumbelliferone) click-here

HEPARVIT™ ProCHEMO

Products containing anti-neoplasm derivatives click-here

ExCELL™

 

Medical research...........

Indicates that umbelliferone derivatives (4-meythylumbellierone) administered: as a adjunct therapy to chemotherapies (gemcitabine and others); as a preventive or management therapy for chemotherapy side-effects and patient recovery.

• Applied as a adminiculum in anticancer chemotherapy, to improve efficacy and tolerability;
• Decreases the size of the primary and metastatic tumors more than gemcitabine alone;
• Strongly suggest that a combination of  gemcitabine and umbelliferone derivatives (4-meythylumbellierone)  and  is effective against human pancreatic cancer cells.
• Reduces elevated liver enzymes associated with chemotherapy toxicity (drug induced Hepatitis);
• Accelerates red blood cell and platelet recovery;
• Improves tiredness, appetite, and the digestive system function;
• Greatly improves tolerability and effect when taken as a anticancer chemotherapy prophylaxis  prior to commencing treatment.

Indicates that the anti-neoplasm derivatives:

•  Promote the generation of the bodies own cancer killing cells;
• Help rebuild a damaged immune system.